tweak

1. slang To use a stimulant drug, especially methamphetamine, for recreational purposes. A: "Hey, Jim, long time no see. Wanna come tweak with us later?" B: "No thanks, man, I gave crank up years ago."

2. slang To behave in a confused, agitated, and psychologically unstable manner as a result of methamphetamine withdrawal. Some junkie on the corner was tweaking so bad that I nearly called an ambulance.

tweaked

slang Intoxicated from an amphetamine or methamphetamine. A bunch of kids at the party were getting tweaked on Adderall. He was so tweaked on meth that I thought he was going to hurt someone.