locked and loaded

1. Loaded with ammunition and prepared to be fired. Are those guns locked and loaded? Because the enemy's a-comin'.

2. Prepared; ready. A: "Please tell me you have all those pamphlets ready for the presentation tomorrow." B: "Yep—locked and loaded!"

See also: and, loaded, lock

See also:

ready up
made from scratch
make (something) from scratch
load into
(as) ready as (one) ever will be
(as) ready as (one) will ever be
loaded for bear
get loaded
drunk
laded with

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