what's with

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What's (up) with (something)?

1. What is the meaning or purpose of the something; why is something happening or the case? What's with these tiny portions? For how much the food costs, I was expecting to get a bit more on the plate. We've been waiting to hear what's up company's new expansion plan.
2. What is wrong with something? Hey, what's with your computer? The screen just keeps flashing when I turn it on.

What's up with (someone)?

1. Why is someone so upset or acting in such an unusual way? What's up with Jeff? He just screamed at me and stormed out of the room. I wonder what's up with Sarah—she's been avoiding me for days now.
2. What is new in someone's life? Oh, hey Jim, what's up with you? Did you end up getting that job in Denver? A: "I ran into Cheryl today." B: "Oh yeah? What's up with her these days?"
See also: up

What's with (someone)?

Why is someone so upset or acting in such an unusual way? What's with Jeff? He just screamed at me and stormed out of the room. I wonder what's with Sarah—she's been avoiding me for days now.
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.

what's with

Also, what's up with; what gives with. What is going on with; tell me about or explain it. For example, What's with all the food they're giving away? or What's up with Lee these days? or What gives with Jack? Why is he so glum? This idiom is also sometimes used as a substitute for how are you or what's wrong, as in Hi, Pam, what's with you? or What gives with you-why are you yelling? [Colloquial; c. 1940]
The American Heritage® Dictionary of Idioms by Christine Ammer. Copyright © 2003, 1997 by The Christine Ammer 1992 Trust. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
See also:
References in periodicals archive ?
What's with that fezzy orange mullet and how do you pick up chicks with that heinous 'do?