1. To desire to disembark (from something) or come down off (of something). Please, this roller coaster is making me sick—I want off! Why didn't you stop? I wanted off the bus three blocks ago! I could tell those poor kids just wanted off that stage.
2. To desire or require for someone to disembark (from something) or come down off (of something). In this usage, a noun or pronoun is used between "want" and "off." I want you kids off the train this instant, or I'll call the police! That slide is for bigger boys and girls, Tommy. I want you off right now!
3. To desire to no longer be taking drugs or medication. The medication they gave me has actually been making me even more anxious lately, so I really want off. She says she wants off the antidepressants, but her doctor doesn't think it's the right time for that yet. I know he wants off heroin, so we need to do everything we can to help him quit.
4. To desire or require for someone to no longer be taking drugs or a certain kind of medication. In this usage, a noun or pronoun is used between "want" and "off." I want you off those drugs if you're going to be staying in our house, understand? The surgeon said she wanted me off blood thinners before she would operate on me.
want off (something)and want off of something
to desire to be off or get off something. (Of is usually retained before pronouns.) I want off of this bus this very minute! Stop this train! I want off!