1. To clean dirt or debris out (of something or some place) with a vacuum cleaner. A noun or pronoun can be used between "vacuum" and "out." With two toddlers, it feels like I'm vacuuming crumbs out of my car nearly every week. I tried to vacuum out most of the dirt, but some of it has gotten caked onto the inside of the tub.
2. To rid something or some place of dirt or debris by cleaning it with a vacuum cleaner. A noun or pronoun can be used between "vacuum" and "out." Make sure you vacuum out your car before you go pick up your mom from the airport. Please vacuum the room out after you have removed all your belongings.
3. By extension, to remove something (from some place or someone's possession) completely and very quickly. A noun or pronoun can be used between "vacuum" and "out." These loan sharks start vacuuming money out of your account if you don't repay what you borrow as soon as possible. Big cities like this one would become incredibly eerie if you were to vacuum out all the people out of them.
vacuum something out
to clean an enclosed area out with a vacuum cleaner. Please vacuum this car out now! Can you vacuum out the car?