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Related to tangles: Neurofibrillary tangles
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tangle up

1. To become tangled. I store each strand of Christmas lights in a separate bag so they don't all tangle up.
2. To entangle or ensnare someone or something in something. In this usage, a noun or pronoun can be used between "tangle" and "up," and the phrase is often followed by "in (something)." You have so many knots that I can't help but tangle the brush up in your hair. Spiders try to tangle up their prey in their webs.
3. To involve or entrap oneself or someone in something, such as an issue, problem, or scandal. In this usage, a noun or pronoun can be used between "tangle" and "up," and the phrase is often followed by "in/with (something)." The best politicians choose their battles wisely and avoid becoming too tangled up in petty debates. My brother has tangled me up with a number of lawsuits to keep me from accessing our late father's estate.
See also: tangle, up

tangle with (someone or something)

To fight, argue, or engage in a dispute with someone or something. I wouldn't tangle with them if I were you. They've got so much money that you'll never stand a chance in court. My brother always had a habit of tangling with kids much bigger than him. Trust me, she is not one to tangle with.
See also: tangle
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.

tangle someone or something up

to entangle someone or something. Please don't tangle me up in your ropes. I tangled up my feet in the cords on the floor.
See also: tangle, up

tangle with someone or something (over someone or something)

to battle against someone or something about someone or something. Tim tangled with Karen over the children. I hope I don't have to tangle with the bank over this loan. I don't want to tangle with city hall.
See also: tangle
McGraw-Hill Dictionary of American Idioms and Phrasal Verbs. © 2002 by The McGraw-Hill Companies, Inc.

tangle up

1. To mix something together or intertwine it in a confused mass; snarl something: I accidentally tangled that rope up with the others. You've tangled up all the paper clips and now I can't separate them. The telephone cord is tangled up in a knot.
2. To catch and hold something in or as if in a net; entrap something: The children tangled the kite up in the branches. I tangled up the fishing lure as I was pulling it through the weeds. A dolphin became tangled up in the fishing net.
3. To involve someone in awkward or unsavory circumstances. Used chiefly in the passive: How did a good kid like you get tangled up with criminals? No politician would want to be tangled up in this sordid affair.
See also: tangle, up

tangle with

To enter into argument, dispute, or conflict with someone or something: The tenants were afraid to tangle with their landlord's expensive lawyers.
See also: tangle
The American Heritage® Dictionary of Phrasal Verbs. Copyright © 2005 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

tangle with someone/something

in. to quarrel or fight with someone or something. It’s like tangling with a grizzly.
McGraw-Hill's Dictionary of American Slang and Colloquial Expressions Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
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References in periodicals archive ?
While the formation of amyloid plaques and tau tangles have been recognized as key steps in the development of Alzheimer's disease, researchers have struggled to pin down the relationship between the two.
To study whether the spread of tau tangles is affected by sleeplessness, the researchers seeded the brains of mice with tiny clumps of tau and then kept the animals awake for long periods.
This paper proposes a constructive steganography algorithm using tangles. With an outline of a natural image and a pre-defined cell library, we can construct a tangle image to hide secret messages through a series of graphic operations.
It also destroyed existing tau tangles and prevented the protein from spreading around the brain of older mice.
From left, Zac James-Cotgrave, Sales Manager at Debenhams, Eloise Davidson, Corporate Partnerships Manager at Birmingham Children's Hospital Charity, Alice Reeve, owner of Francesco's Hair Salon and Lichfield Ladies Tangles member, Rachel Anslow, Store Manager at Debenhams, and Sue Jay, Chairman of Lichfield Ladies Tangles
The study was discussed Wednesday at the Alzheimer's Association International Conference in Copenhagen, where researchers also described a new type of brain imaging that can show tau tangles in living people for the first time.
The current study demonstrated that not only stroke risk, but also the burden of plaques and tangles, as measured by a UCLA brain scan, may influence cognitive decline.
In Section 2, we describe the tangle decomposition of a (3 + 1)-free poset into clone sets and tangles and use it to compute the poset's automorphism group.
"Researchers are making real advances," says Rudolph Tanzi, PhD, Director of the Genetics and Aging Research Unit at MGH's Institute for Neurodegenerative Diseases "They are not just looking at plaques and tangles, they're looking at the components of plaques and tangles."
Destructive knots of protein fibres called tau tangles spread through the brains of the injected mice.
They owe their quick wits to a lack of fibrous tangles which normally make an appearance in the brain late in life.
CHICAGO -- An experimental drug designed to attack neurofibrillary tau tangles significantly improved some measures of memory among patients with mild cognitive impairment, although it failed to meet its primary cognitive end point.
Rember is the first drugto act on the tau tangles that develop in the brains of people with Alzheimer's disease.
Rember is the first drug to act on the tau tangles that develop in the brains of people with Alzheimer's disease.