At once; immediately; without delay or hesitation. When I walked in the room, I knew straight off that something bad had happened between my brothers. When we land, we'll be catching the next flight straight off—there is no layover.
frankly; directly. Bob told Pam straight out that he didn't want to marry her. Jim was told straight out to start working harder.
Also, straight away. Immediately, as in I knew straight off that he was lying, or I'll get to the dishes straight away. The first term dates from the late 1700s, the variant from the mid-1600s.