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1. To continue trying to do or achieve something, especially after initial failures, challenges, or setbacks. Used especially in the phrase "stick at it." If you really want to become a comic book artist, you have to stick at it! You can't just give up after your first rejection. I'm really glad I stuck at this book—it was a bit arduous at times, but it was really interesting overall!
2. To do whatever it takes to accomplish a task or goal; to refuse to allow anything to impede one from doing or achieving something. Used exclusively in the phrase "stick at nothing." They made it clear that they would stick at nothing to recoup the cost of their investment. She's the type of woman who will stick at nothing to get what she wants from life.
stick at something
to keep trying to do something; to stay on a task or job. I hope he can stick at this job. He doesn't seem to be able to stick at anything for very long.
Scruple or hesitate, as in She sticks at nothing to gain her ends. This idiom, nearly always used in a negative context, was first recorded in 1525. Also see stop at nothing.