These results have given us hope that the new SHIVs will indeed be a game-changer for HIV vaccine research," Shaw said.
This discovery represents a novel and generalizable strategy for constructing SHIVs with envelope glycoproteins of particular interest, including those that elicit broadly neutralizing antibodies in humans or ones that bind particular B cell receptors.
Now, Shaw, Li, and their colleagues have found a way to overcome these obstacles and to make a much better SHIV -- one that closely mimics HIV infection in humans.
In the PNAS study, Li and Shaw hypothesized that changing the binding affinity of the HIV envelope to rhesus monkey CD4, the primary receptor for HIV, would be the key to successful SHIV design.
They have already observed in numerous infected animals that the SHIV virus and host antibody response are evolving in ways that closely resemble human infection by HIV-1.
Regional media has reported several instances of Shiv Sena leaders expressing their views against an overtly explicit approach towards an alliance through messages written on black boards placed in public places.
Shiv Sainiks put up boards appealing leaders to show selfrespect.
Hope @ ShivSena leadership takes signals & prepare to sit in opposition," former Shiv Sena MP Bharat Kumar Raut said in a tweet later.
BJP is keen to have a post- poll alliance with Shiv Sena.
