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To admit defeat and/or plead for mercy, especially in an informal physical contest of some kind. Can also be used as an imperative phrase to demand that someone give up or admit defeat. The brothers often play fought, but it was invariably the younger of the two who had to say uncle by the end. Say "uncle," and I'll let you out of this headlock!
cry/say ˈuncle(American English) admit that you have been beaten or defeated: They’re determined to make the President cry uncle in the budget debate.Originally, this comes from children’s games in which the child has to say the word ‘uncle’ to admit defeat.
tv. to admit defeat; to give up. I never say uncle. I just keep right on going.