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1. Literally, to extract or remove something from something else with great force, especially with the use of a lever. A noun or pronoun can be used between "prize" and "out." I had to prize out all the rusty nails with the claw end of a hammer before we could begin repairing the damage to the fence. The sheriff prized the gun out of the suspect's hands.
2. To obtain or extract something, especially information, from someone with great effort, difficulty, or persistence. A noun or pronoun can be used between "prize" and "out." I had to prize the answer out of her when I asked where she had been. It was only after the judge threatened to charge him with contempt of court that his testimony was prized out of him.