1. To prepare oneself by applying powder of some kind. Make sure you powder up before you put on that equipment, or it will chaff you really badly. Excuse me a moment, I'm just going to the restroom to powder up.
2. To coat something with liberal amounts of powder, typically talcum powder. In this usage, a noun or pronoun can be used between "powder" and "up." She said she powders her thighs up to keep them from chaffing when she wears a skirt or dress. I powder up the inside of my shoes with antifungal medication to combat my athlete's foot.
3. To crush something completely into powder. In this usage, a noun or pronoun can be used between "powder" and "up." You'll need to powder this up before dissolving it in a chemical solution. He powdered up the pills and snorted them up his nose.
slang Intoxicated with cocaine (which is typically ground into a powder and snorted into one's nostrils). I could tell by her eyes, her twitchy behavior, and her constant sniffing that she was totally powdered up. We spent the whole night drinking beer and getting powdered up.
See powdered up
See also: powder
mod. alcohol intoxicated. Most of the bums in the gutter are really powdered.