1. To introduce some kind of poison into a person's or animal's system in order to sicken or kill them. A noun or pronoun is used between "poison" and "with." She slowly poisoned John with small doses of arsenic over the course of several years. Someone has been poisoning local wildlife with antifreeze.
2. To lace, taint, or coat something with some kind of poison. A noun or pronoun is used between "poison" and "with." Someone poisoned the soup with cyanide. The tribe poisons the tips of their arrows with a substance found on the backs of certain frogs.
3. To pollute or dirty something with some toxic, poisonous, or otherwise harmful substance. A noun or pronoun is used between "poison" and "with." The nuclear power plant has been accused of poisoning the city's water supply with poorly contained toxic waste. If we continue to poison the atmosphere with all the CO2 our cars and factories belch out, we're going to make our planet uninhabitable in a matter of years!
poison (someone or an animal) with something
to render someone or an animal sick or dead with a poison. He intended to poison his wife with arsenic. Barry wanted to poison the cat with something that left no trace. He poisoned himself with the cleaning compound.
poison something with something
to render something poisonous with something. She poisoned the soup with arsenic. They are poisoning our water supply with pollutants.