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To make or become more lively, energetic, attentive, cheerful, dynamic, etc. I wish you would perk up. There are so many exciting things happening, and you're just moping there in the corner! I think I need some coffee to perk me up. I always use some red chilies to perk up my soups and stews.
mod. alcohol intoxicated. (see also pepped (up).) No more. She’s done. She’s perked up for good.