Inverse ratio ventilation has not been demonstrated, however, to confer any advantage over conventional ventilation with external PEEP in improving gas exchange.
Another point of investigative interest concerns the use of applied PEEP in passively ventilated patients with airflow obstruction.
Positive end-expiratory pressure devices have been used to reduce ventilatory work, improve gas exchange and counteract intrinsic PEEP in
patients receiving mechanical ventilation, (20), (21) but to our knowledge, this technique has not been used on an intermittent basis in nonventilated subjects.
We did not aim in this study to investigate the optimal value of PEEP in
Van der Zee (33) and colleagues, however, noted no change in normal lungs, but a decrease in pulmonary QL with PEEP in
animals with alloxan-induced vascular injury.
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