overdose

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overdose on (something)

To experience an extreme, life-threatening physical reaction to too large or too many doses of some drug, especially heroin, opioids, cocaine, or amphetamines. I thought I was overdosing on my medication when I started losing consciousness like that. My brother eventually overdosed on morphine after getting addicted to it following his surgery.
See also: on, overdose

overdose with (something)

1. To experience an extreme, life-threatening physical reaction to an excessive size or amount of doses of some drug, especially heroin, opioids, cocaine, or amphetamines. My brother eventually overdosed with morphine after getting addicted to it following his surgery. A lot of people don't even think about the possibility of overdosing with over-the-counter pain killers.
2. To cause someone else to experience such a reaction by administering a drug to them. In this usage, a noun or pronoun is used between "overdose" and "with." He lost consciousness because the nurse overdosed him with the medication.
3. To ingest an excessive amount something, especially to the point of discomfort or displeasure. Usually used jocularly or lightheartedly. I don't feel so good—I think I overdosed with chocolate! We felt like we had overdosed with salt after eating so many potato chips.
4. To give or apply an excessive amount of something to someone or something, especially to the point of discomfort or displeasure. In this usage, a noun or pronoun is used between "overdose" and "with." My mom always overdoses us with chocolate chip cookies whenever we come home for the holidays. Don't overdose the sauce with pepper this time!
See also: overdose
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.

overdose (someone) (on something)

 and overdose someone with something
to give someone too much of some substance, usually a drug. The police say he overdosed on heroine. Sam overdosed his sister on the cough medicine. She overdosed herself with aspirin.
McGraw-Hill Dictionary of American Idioms and Phrasal Verbs. © 2002 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
Nathan, of Stone, Staffs, had overdosed on alcohol and paracetamol in April 2011, the Cannock inquest heard.
Minutes after the University of Maryland basketball player overdosed on cocaine, he developed an erratic, uncontrollable heartbeat.
People who have overdosed on opioids generally present with evidence of obtundation, miosis, and difficulty breathing.
In addition to the public health investigation, a public safety investigation was conducted; comprehensive opioid toxicology testing of clinical specimens identified the synthetic opioid fentanyl * and novel fentanyl analogs, including carfentanil, ([dagger]) which had been used by patients who overdosed in Huntington.
The late, legendary singer Prince overdosed last week from a prescription medication called Percocet, according to a (http://www.tmz.com/2016/04/22/prince-od-percocet-death/) new report Friday.
For example, they said they were unable to identify the source of prescription opioids among the people who overdosed, "and many individuals who misuse opioids do not obtain then directly from physician prescriptions."