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overdose on (something)

To experience an extreme, life-threatening physical reaction to some narcotic, especially heroin, opioids, cocaine, or amphetamines. I thought I was overdosing on my medication when I started losing consciousness like that. My brother eventually overdosed on morphine after getting addicted to it following his surgery.
See also: on, overdose

overdose (someone) (on something)

 and overdose someone with something
to give someone too much of some substance, usually a drug. The police say he overdosed on heroine. Sam overdosed his sister on the cough medicine. She overdosed herself with aspirin.
References in periodicals archive ?
Nathan, of Stone, Staffs, had overdosed on alcohol and paracetamol in April 2011, the Cannock inquest heard.
Minutes after the University of Maryland basketball player overdosed on cocaine, he developed an erratic, uncontrollable heartbeat.
In addition to overdose rescue training and purchasing naloxone, communities may use the funding to promote the states Good Samaritan Law which encourages anyone who witnesses an overdose to seek help from professionals by providing the caller, and the person who overdosed, protection from arrest and prosecution for drug possession.
People who have overdosed on opioids generally present with evidence of obtundation, miosis, and difficulty breathing.
In addition to the public health investigation, a public safety investigation was conducted; comprehensive opioid toxicology testing of clinical specimens identified the synthetic opioid fentanyl * and novel fentanyl analogs, including carfentanil, ([dagger]) which had been used by patients who overdosed in Huntington.
The late, legendary singer Prince overdosed last week from a prescription medication called Percocet, according to a (http://www.tmz.com/2016/04/22/prince-od-percocet-death/) new report Friday.
For example, they said they were unable to identify the source of prescription opioids among the people who overdosed, "and many individuals who misuse opioids do not obtain then directly from physician prescriptions."