1. Important or significant. We only have a limited amount of time in which to conduct this meeting, so let's please stick to matters of consequence.
2. Famous. Once people found out my brother was a person of note, everyone suddenly wanted to be my friend. She was the only person of consequence at the party, so once she left, I felt there was no longer a reason to stay.
someone of note
a person who is famous. We invited a speaker of note to lecture at the next meeting. The baseball player of note was inducted into the Hall of Fame.
Important, of distinction, famous, as in I have nothing of note to report, or The speaker was a man of note. This idiom uses note in the sense of "importance" or "fame." [Late 1500s]