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1. It doesn't matter; it's not important. A: "Sir, we've detected a leak in the hull." B: "No matter, we'll be pulling into port shortly." I could have dropped him off when I went out to get groceries, but no matter.
2. Despite; irrespective of. We'll get her the very best treatment available, no matter the cost!
1. It's not important, as in She wasn't home when I came by, but no matter. [Mid-1500s]
2. Also, no matter what. Regardless, it makes no difference, as in No matter what I say, she'll do what she likes, or The car must be repaired, no matter what. [Mid-1500s]
Regardless of: "Yet there isn't a train I wouldn't take, / No matter where it's going" (Edna St. Vincent Millay).