murder on

be murder on (someone or something)

To cause a lot of harm, distress, or ill effects to someone or something. Staring at this computer screen all day has really been murder on my eyes! I just think working in the evenings and having to get up with the kids in the morning is going to be murder you.
See also: murder, on

murder on something

very destructive or harmful to something. Running a marathon is murder on your knees. This dry weather is murder on my crops.
See also: murder, on