be murder on (someone or something)
To cause a lot of harm, distress, or ill effects to someone or something. Staring at this computer screen all day has really been murder on my eyes! I just think working in the evenings and having to get up with the kids in the morning is going to be murder you.
murder on something
very destructive or harmful to something. Running a marathon is murder on your knees. This dry weather is murder on my crops.