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make life miserable for (one)
To cause one to be continually unhappy; to be a great and continuous source of stress for one. For some reason, the new manager seems to have decided to make life miserable for me. Don't worry, we'll make life miserable for them is they refuse to sign the contract.
make (oneself) miserable
To cause oneself a great amount of stress, anxiety, sadness, etc. I don't understand why she keeps making herself miserable in a job she hates. She's just not interested in you romantically, Jack, so stop making yourself miserable pining over her!
(as) miserable as sin
Extremely unhappy, depressed, or wretched. Everyone just stood around looking miserable as sin during the ceremony. I felt as miserable as sin because of the breakup, but I was going to be best man at my brother's wedding, so I had to pick myself up and dust myself off.
(as) ugly as sin
Extremely visually displeasing or unattractive. I wouldn't buy that painting, it's as ugly as sin. I'm sure I looked ugly as sin, with my makeup smeared all over and my hair a total mess.
make life miserable for someone
to give someone misery; to be a great nuisance to someone. This nagging backache is making life miserable for me. I wish you would stop making life miserable for me.
make oneself miserable
to do things which cause one to be unhappy. You're just making yourself miserable by trying to do something you aren't qualified to do. I'm not making myself miserable! You're making me miserable.