Laboratory or questionnaire data were obtained for 153 (19%) children, of whom 17 (11.1%) had illness meeting the case
definition for histoplasmosis (five confirmed, 12 suspected).
Primary symptoms reported among the 20 ill persons meeting the case
definition included fatigue (100%), fever or chills (95%), and headache (95%) (Table 1).
As expected, fewer persons who did not have illness meeting the case
definition had discrete onset of symptoms or laboratory evidence of liver injury; however, because these criteria are included in the case definition for hepatitis A, tests of statistical significance for differences between the two groups were not performed.
Among the 35 patients with illnesses meeting the case
definition, nine (26%) have laboratory evidence of clostridial infections based on culture isolation or 16S ribosomal DNA polymerase chain reaction and sequencing performed on blood or tissue, including three C.
Of the 1194 athletes surveyed, 110 (9%) who participated in one or both events described an illness meeting the case
definition; no cases occurred after July 24.
Although the methodology of these surveys differed, the prevalence of valvular disease meeting the case
definition was similar in all five survey populations, ranging from 30.0% to 38.3% (overall: 32.8%; 95% confidence interval=27.7%-38.9%) (Figure 1) (Division of Pharmacovigilance and Epidemiology, Center for Drug Evaluation and Research, FDA, personal communication, 1997).