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off (one's) meds

1. Literally, not taking one's prescribed medications. I've been able to think more clearly after going off my meds—my mind doesn't feel as foggy. I knew as soon as she walked in that she was off her meds—she never acts that way when she's on her regimen.
2. Crazy or insane. Potentially offensive due to the implication of mental illness. She's off her meds if she thinks she can come in here and talk to me in that tone of voice! When Paul suddenly decided to pick up and move across the country, everyone said he must be off his meds.
See also: med, off

off one’s meds

phr. acting strangely. Man, what a temper! Must be off her meds.
See also: med, off
References in periodicals archive ?
The continued strong interest in Med Gen increases liquidity and gives rise to major investment opportunities, joint ventures, mergers and acquisitions.
but eating the way Bronwyn describes in her book UNDIET is not only proven through testimonials as the correct way, but it carries with it the philosophy behind Med Gen's Un-Diet(TM) system; Weight Control System For Life.
Since its existence, Med Gen has continued to develop its "sprays the way" technology, introducing Good Night's Sleep(R) and most recently the UNDIET(TM) weight loss plan.
E[acute accent]This Press Release contains or incorporates by reference "forward looking statements including certain information with respect to plans and strategies of Med Gen Inc.
The Distribution Agreement covers all products now being manufactured by Med Gen.
Ireland is the first country to receive Med Gen products from AUIT and the company expects that it will be followed up over the next few months with orders on a country-by-country basis.