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major in (something)
To complete a college or university degree with a particular subject as its focus. Originally I thought I would major in English literature, but I switch to psychology in my second year. Samantha's majoring in economics, with a minor in history.
An area, echelon, or sphere of great competition, success, power, achievement, etc. Refers to the major leagues of sports teams. I know you're new here, but you need to perform much better if you want to stay in this law firm. You're in the major leagues now. Welcome to the major league of politics, senator.
major in something
to specialize in a certain subject in college. I majored in history in college. I want to major in math.
To complete a long-term course of study in some subject that is one's main focus: In high school I was interested in math, but in college I majored in history.
mod. excellent; serious; severe. (Collegiate.) This rally is, like, major! Nick is a major dweeb.