lose one's buttons
lose (one's) buttons
To be or become mentally deficient, incompetent, or deranged; to become of unsound mind. My poor grandmother started losing her buttons after she had a stroke on her 84th birthday. I've been so sleep deprived lately that it feels like I'm losing my buttons!
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.
lose one's buttons
see under have all one's buttons.
The American Heritage® Dictionary of Idioms by Christine Ammer. Copyright © 2003, 1997 by The Christine Ammer 1992 Trust. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.