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chance of a lifetime
An extremely important and/or fortuitous opportunity, especially one that is not likely to ever present itself again. Often (but not always) used hyperbolically. They offered me the chance of a lifetime to travel the world and write about my experiences abroad. Make sure you take advantage of our sale, it's a chance of a lifetime!
a legend in (one's) own lifetime
A person who has an extraordinary level of fame or reputation while they are still alive. The singer has made such a huge impact on the world of blues that she's come to be a legend in her own lifetime.
Why break the habit of a lifetime?
A rhetorical question expressing doubt that someone will change their bad habit. Typically said after that person has announced their intention to stop such a habit. A: "That's it. That's my last cigarette." B: "Why break the habit of a lifetime?"
once in a lifetime
Describing something, such as an opportunity, experience, or situation, that seems unlikely to happen again. You have to take this job in the Zurich office—it's a once in a lifetime opportunity to live in Switzerland.
of a lifetime
Used to describe something extremely important, enjoyable, or exceptional, especially that which isn't likely to occur again. They offered me the chance of a lifetime to travel the world and write about my experiences abroad. That tour around Europe really was the trip of a lifetime!
once-in-a-lifetime chanceand once-in-a-lifetime opportunity
a chance that will never occur again in one's lifetime. This is a once-in-a-lifetime chance. Don't miss it. She offered me a once-in-a-lifetime opportunity, but I turned it down.
See also: chance
once in a lifetime
Extremely rare, especially as an opportunity. For example, An offer like that will come just once in a lifetime. This phrase, often used hyperbolically, was first recorded in 1854. Also see of one's life.