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To be energetic and excited, possibly with nerves. A noun or pronoun can be used between "key" and "up." It's Christmas Eve, and the kids are totally keyed up. Waiting for the doctor to call with my test results has really keyed me up.
Excited, nervous, or anxious. I'm so keyed up after that concert that there's no way I'm going to be able to fall asleep. Ben gets a little keyed up before he goes on stage, but once he's out there, he's completely in control.
*keyed up (about something)and *keyed up (over something)
to be excited or anxious. (*Typically: be ~; get ~.) Why are you so keyed up about nothing? She is keyed up over her son's health.
1. mod. nervous; anxious. Sally was a little keyed up before the meet.
2. and keyed up to the roof mod. alcohol or drug intoxicated. He was a mite keyed, but still technically sober. Tipsy, hell! I’d say keyed up to the roof!