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'By applying it in the skin in a very directed fashion we can selectively ablate the neurons which are causing the itch - much like performing microsurgery using light.'
To test whether NPPB was involved in itch signaling to the spinal cord, Mishra and his team used IL-31 to trigger itchiness in mice.
Itch severity was assessed as described by Oaklander et al., with a score on the itch-intensity assessment scale between 1 and 3 points representing a grade of "mild," a score between 4 and 7 points representing a grade of "moderate," and a score of 8 points or greater representing a grade of "severe" [3].
TriCalm effectively reduced peak itch intensity by about 3 points on a visual analog scale--a 41% reduction.
The aim of the present study was to investigate whether healthy participants focus their attention at or away from the tonic itch and pain stimulus location.
But the mice appeared normal in other ways: They responded to pain and itchy chemicals in the same way normal mice do, suggesting the body has a dedicated, specific way of detecting mechanical itch, Ma says.
The finding, in mice, suggests the old wives' tale about resisting the urge to scratch an itch has a scientific basis.
Scientists have known for decades that scratching creates a mild amount of pain in the skin, said senior investigator Zhou-Feng Chen, PhD, director of Washington University's Center for the Study of Itch. That pain can interfere with itching -- at least temporarily -- by getting nerve cells in the spinal cord to carry pain signals to the brain instead of itch signals.
These associations were even more significant in adolescents who reported eczema with itch, compared with those who had eczema without itch.
Louis has even opened The Center for the Study of Itch, and they've made some surprising discoveries.
Cold weather and a lack of fluid can also dry out skin, a problem called winter itch. A rise in body temperature after exercise may also cause itching as well as hives.
Living with Itch: A Patient's Guide provides a powerful coverage and comes from itch researchers and clinicians who consider the physiological events that cause itch.
South Miami, FL, December 05, 2013 --( An innovative new product designed to provide its users with a convenient manner of scratching a difficult to reach area, the Columbus Itch Scratcher, has been developed by Jim Columbus of Sarasota, Florida.
Patients with psychogenic itch predominantly are female, with average age of onset between 30 and 45 years.