slang Having contracted the viral infection herpes, particularly the strains that are transmitted through kissing or sexual contact. That's a cold sore, all right. Looks like you got herped-up, man.
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.

herped up

mod. infected with the herpes simplex virus. Why do all the boys treat me like I was herped up or something?
See also: herped, up
McGraw-Hill's Dictionary of American Slang and Colloquial Expressions Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
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