Bertrand et al., "Experience with Intraamniotic Thyroxine Treatment in Nonimmune Fetal Goitrous
Hypothyroidism in 12 Cases," The Journal of Clinical Endocrinology & Metabolism, vol.
Smoking habit: 17.3 per cent of goitrous
children and 18.8 per cent of control children had history of passive smoking (P=0.82) and none were active smoker.
We studied 17 selected unrelated patients with iodide organification defect (perchlorate discharge test [greater than or equal to]30%) from an original cohort of 40 patients with congenital goitrous
hypothyroidism at screening.
* The most common single pathological diagnosis was Goitrous
lesion of thyroid followed by tuberculous affection of lymph node.
Thyroid gland was considered goitrous
when its total volume exceeded +2 standard deviation (SD) score of the volume found by Kurtoglu et al (25) for Turkish newborns of different gestational ages.
Effect of zinc supplementation on the zinc level in serum and urine and their relation to thyroid hormone profile in male and female goitrous
From the above chart it may be seen that the blood iodine curve does not rise to such a high level in the hyperthyroid individual as in the normal or nontoxic goitrous
patient." The last paragraph of this manuscript reads: "An iodine tolerance test is described which may prove to be a valuable asset in establishing a diagnosis of hyperthyroidism."
TPO defects are believed to be among the most frequent causes of abnormalities in thyroid iodide organification defect causing goitrous
Autoantibodies against thyroglobulin, [T.sub.3], and [T.sub.4] have been documented in the setting of hypothyroidism, hyperthyroidism, and goitrous
states and may be present in up to 1.8% of the euthyroid general population (3-5).
In the course of the work in various neighborhoods, family histories naturally were widely discussed, children reported other cases of goiter occurring in other members of their families, and finally careful studies of the family history of the goitrous
pupils were made exhaustively in certain selected neighborhoods, with the interesting finding that almost universally the percentage of goiter in the mothers of goitrous
children was much higher than that in the rest of the community.
 The goitrous
form of Hashimoto's thyroiditis occur because of acquired defect in hormone synthesis with elevated level of TSH.
Mutations in the DUOXA2, DUOX2, and TPO genes are responsible for thyroid dyshormonogenesis and goitrous
congenital hypothyroidism (GCH) (3,4,5).
Hashimoto's thyroiditis is now classified as goitrous
autoimmune thyroiditis because the gland is enlarged, in distinction to atrophic autoimmune thyroiditis where atrophy and fibrosis are predominant.
Moreover, because goitrous
changes in the thyroid gland or the development of thyroid nodules often do not alter thyroid function, a TSH concentration within the reference interval in a patient with one of these structural abnormalities provides only part of the necessary information and does not mean that the patient's thyroid condition is innocuous.
The most common single pathological diagnosis was Goitrous
lesion of thyroid accounting 38% of cases followed by Tuberculous lymphadenitis (11%).