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The state or quality of having a given amount of positivity, energy, ambition, and/or determination. That new intern we hired sure has a lot of get-up-and-go! You're going to need more get-up-and-go if you want to succeed in this business!
get-up-and-goenergy, enthusiasm, and initiative. informal
A mid 19th-century US colloquialism was ‘get up and get’.