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People say game on to mean that they are ready for something challenging to begin. You think you can beat me? Game on! Note: You can also say it's game on for someone to mean that they are about to face a challenge. It's game on for toy makers as Christmas approaches.
game on1 a signal for play to begin in a game or match. 2 said when you feel that a situation is about to develop in your favour. informal
2 1999 FHM She soon invited me back to her place for the other. Game on!