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The new syndrome, pathological though it may be, will have to produce in addition an excusing condition.
Thus, the real argument should be about the genuine excusing condition that is doing the work.
My preferred candidates are irrationality and internal and external coercion, which I believe quite closely track moral and legal excusing conditions and which can be normatively defended.
New syndromes excuse only if they sufficiently produce whatever excusing condition the law and morality adopt.
Assuming that a particular syndrome causes rationality problems or other excusing conditions, not all syndrome sufferers will be equally irrational or the like.
Unfortunately, there are no generic excusing criteria, but only discrete defenses, such as legal insanity.
Defendants should be able to use any credible, and I stress credible, lay or expert evidence to demonstrate that they were nonculpably in the generic excusing condition at the time of the crime.