Von Willebrand factor
cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis).
DNAzymes, like Ribozymes, are nucleic acid molecules with enzy matic activity and can be engineered to act as "molecular scissors" capable of, for example,
cleaving target RNA in a highly specific manner.
If MAPK inhibition is the explanation for anthrax's actions, says Duesbery, compounds that block LF's
cleaving action--so-called protease inhibitors--might be a useful therapy for the disease.
He believes that the new method's primary contribution may be simply to spark inquiry into other, related methods of
cleaving nitrogen molecules.
Together with David Platt, also at MCF, Raz created such pectin molecules by
cleaving the normally branch-shaped citrus pectin into linear subunit with a single, free galactoside.
All bioluminescent beetles, including fireflies, produce colored light by enzymatically
cleaving molecules of an identical protein substrate, called luciferin.
They especially wanted an image of the enzyme's active site -- the three-dimensional cleft into which proteins in need of
cleaving nestle.
A reactant chemical, dissolved in the isooctane, penetrates into the reverse micelles, where the abzymes catalyze reaction, in this case
cleaving the phenylacetate molecules.
