[73.] Karathanasis, E., Ayyagari, A.L., Bhavane, R., Bellamkonda, R.V., and Annapragada, A.V., Preparation of in-vivo cleavable
agglomerated liposomes suitable for modulated pulmonary drug delivery.
Subsequently, the break is sealed and the linkage number is changed by 1, and permit essential cellular process (i.e DNA replication, recombination,repair and transcription )to occur.The camptothecins definitely bind to topoisomerase I and stabilize DNA-topoisomerase I cleavable
Gordonite occurs there as layers less than 1 mm thick of clear, glassy, cleavable
crystals encrusting variscite or very near to it.
A new class of cleavable
fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis.
(131) The invention related to a method for producing a protein, human growth hormone (HGH), by using bacteria to first generate a larger protein and then cleaving off the undesired portion with a technique called cleavable
In these works (7), (10), (12), dissolvable hydrogels with cleavable
crosslinkers were designed and fabricated in microfluidic channels.
The topics include delineating protease functions during cancer development, positional scanning synthetic combinatorial libraries for substrate profiling, imaging specific cell surface protease activity in living cells using re-engineered bacterial cytotoxins, and on-demand cleavable
linkers for radio-immunotherapy.
Washington State University (Pullman, WA) has patented novel protein interaction reporter (PIR) compounds (e.g., formulas I and II), comprising at least two protein reactive moieties (e.g., N-hydroxysuccinamide), each linked to a reporter moiety (e.g., mass reporter) by a covalent labile bond that is differentially cleavable
with respect to peptide bonds (e.g., by a method such as collisional activation in a mass spectrometer, activation by electron capture dissociation, photoactivation, etc.), wherein the reporter moiety is operatively releasable from the PIR agent upon cleavage of the labile bonds, the released reporter moiety having a characteristic identifying property or label (e.g., m/z value).
It is reported that for medical use the cleavable
[TEXT NOT REPRODUCIBLE IN ASCII], white, odorous, very astringent, non-sticky one is preferred, which consists of hairy particles [TEXT NOT REPRODUCIBLE IN ASCII].
Analysis of the Msa sequence with eight signal peptide prediction programs showed a consensus that Msa has a cleavable
N-terminal signal peptide that mediates its targeting into the membrane.
crosslinker based on methacrylic anhydride was also found to be necessary for improved mechanical properties and significantly reduced the swelling of the polymer in the monomer formulation.
The products are selectively cleavable
under mild conditions, and after the reaction, besides the desired product also its initial amine component can be resynthesized.
SGN-35 is an ADC comprised of an anti-CD30 antibody joined by an enzyme cleavable
linker to a synthetic drug payload, monomethyl auristatin E (MMAE), using Seattle Genetics' proprietary technology.
The acquisition of a highly cleavable
HA converted an avirulent strain to virulence in Pennsylvania in 1983 (H5N2), Mexico in 1994 (H5N2), Italy in 1997 (H7N1), Chile in 2002 (H7N3), and Canada in 2004 (H7N3) (Table).