Nearly, predictably, or imminently over, finished, complete, defeated, or dead. It's all up for me, Billy. Before I die, take this letter to my wife. It think it's safe to say that it's all up for the home team. They fought a good fight, but there's no overcoming their opponent's lead now.
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.
Defeated; also, near death. For example, The home team knew it was all up when their star quarterback was injured, or The party lost their way over a week ago and in this subzero weather I'm sure it's all up with them . This idiom uses up in the sense of "finished." [Early 1700s] Also see all over, def. 4.
The American Heritage® Dictionary of Idioms by Christine Ammer. Copyright © 2003, 1997 by The Christine Ammer 1992 Trust. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.