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afflict (one) with

1. To cause one to contract an ailment or disease. A person's name or pronoun can appear before "with." My classroom has been almost empty all week because one kid afflicted the others with chicken pox. When you have a child in preschool, you'll be afflicted with every illness.
2. To cause another person hardship or difficulty. When used in this sense, a noun or pronoun typically does not appear between "afflict" and "with." Once I finally recovered from my illness, I was afflicted with medical bills.
3. To force someone to spend time with an irritating person. A person's name or pronoun typically appears before "with." Please don't afflict me with your obnoxious brother this evening.
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afflict someone with someone

to burden someone with an annoying person. I was foolish enough to afflict myself with my young cousin for the weekend.
See also: afflict

afflict someone with something

1. Lit. to cause someone to suffer from a disease or disability. The virus has afflicted everyone in the valley.
2. Fig. to burden someone with trouble. We were afflicted with all the worry that comes with raising a teenager.
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References in periodicals archive ?
ALS afflicts about 20,000 people in the United States.
The animal suffered from a type of pneumonia that often afflicts children with AIDS and from skin tumors that resemble those seen in Kaposi's sarcoma, the bluish-colored growths that often afflict people with AIDS.
A new scientific report supports previous research indicating that cell therapy, a controversial treatment unlicensed by the federal government, provides no benefit to children with Down's syndrome, a genetic disorder that afflicts about one out of every 800 infants born in the United States.
Texas researchers have developed and tested a new fluoride and calcium therapy for spinal osteoporosis, a type of porous bone disease that afflicts 5 million people in the United States, predominantly elderly women.
Chlamydia, which has been called the veneral disease of the '80s, is a bacterial infection that afflicts between 3 million and 10 million women and men in the United States each year, more than are afflicted by syphilis, herpes or gonorrhea.