turning point
The point at which some event, activity, situation, condition, etc., begins or is able to change or reverse course. Little did I know that the meeting would mark a major turning point in my career. We're hoping that this new medicine will prove to be a turning point in the treatment of her disease. The turning point came when the team's captain scored an amazing goal from midfield. After that, it seemed like all the momentum shifted to their side.
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