something is up with (someone or something)

Something is or seems wrong, unusual, or abnormal about someone or something. Hey, something is up with this computer. It's making all sorts of weird noises. I think something's up with Jacob. He's been really moody all day long.

See also: something, up

See also:

a casualty of (something)
a whole different animal
a whole different ball of wax
a whole different beast
(something) to go on
(someone or something) promises well
a/the feel of (something)
(I) wouldn't (do something) if I were you
a straw will show which way the wind blows
accompanied by (someone or something)

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