What's the matter?

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What's the matter (with someone or something)?

What is going on (with someone or something)? What is wrong or the problem (with someone or something)? Hey, what's the matter? You look distressed. What's the matter with this computer? It keeps turning off all on its own. What's the matter with Sarah? She's been in a foul mood all day.
See also: matter, someone

What's the matter?

 and What's the matter with you? 
1. Lit. Is there something wrong with you?; Are you ill? Bill: What's the matter with you? Fred: I have this funny feeling in my chest. Bill: Sounds serious. Bob: I have to stay home again today. Bill: What's the matter with you? Have you seen a doctor? Mary: Oh, I'm so miserable! Sue: What's the matter? Mary: I lost my contact lenses and my glasses. John: Ouch! Alice: What's the matter? John: I bit my tongue.
2. Inf. How very stupid of you! How can you be so stupid? (Usually said in anger.) As Fred stumbled over the step and dumped the birthday cake on the floor, Jane screamed, "What's the matter with you? The party is in fifteen minutes and now we have no cake!" Mary: I think I just lost the Wilson account. Sue: What! What's the matter with you? That account pays your salary!
References in classic literature ?
What's the matter with you? What's the matter with you, shipmate?
'Well, Wilkins, what's the matter with you?' said Captain Boldwig.
"NOW what's the matter with you? If you didn't like them beans--"
"What's the matter with you? That's not funny, that's not entertaining.
What's the matter with you? Why don't you close your open door - the same as they do on a foreign shore.
I just whispered in her ear, 'What's the matter with you?' She said, 'I don't know - I'm high!'" the Daily Express quoted him as saying.
"What's the matter with you?" screamed Corrie's calculating killer as the jury returned their guilty verdict.
What's the matter with you? You're going to depress people."