A nickname for San Francisco, California (based on a shortening of "Frisco," another nickname for the city). I've been living in The Sco for a few years now, and I can't imagine anywhere else I'd like to be. There's a huge tech scene in The Sco at the moment.
See also: Sco
1. n. Frisco; San Francisco. If you ever get back to Sco, look me up.
2. imperative Let’s go! It’s late! Sco!