As these agents are given by intramuscular injection, one of the side-effects is pain at the injection site.
Neoadjuvant and adjuvant chemotherapy are given using multiple drug regimens to achieve maximum efficacy, but this leads to an increase in side-effects. All side-effects are increased in patients >60 years and in those with comorbid medical conditions, e.g.
Most of the drugs used have some or all of these side-effects, which are very rarely problematic.
All side-effects, except for alopecia, are manageable and reduced or eliminated by premedication and dose scheduling according to body surface area.
Side-effects include skin rash, myelosuppression, neurotoxicity, fatigue, nausea, vomiting, diarrhoea and myalgia and arthralgia.
This paper reports side-effects attributed to MDT, the frequency and stoppage of the MDT components in a Health Unit in Vitoria, Brazil.
A specific questionnaire was prepared to collect data from the patient records, and detailing occurrence of side-effects and stoppage of the drug because of side-effects.
Side-effects attributed to MDT were defined as the presence of undesirable secondary effects of onset after the start of MDT.
Side-effects were attributed to at least one MDT component in 88 (45%) patients; 85 had side-effects due to dapsone, 24 due to rifampicin and 18 due to clofazimine.
'As many as 89 per cent of women had some kind of side-effect
recorded in their medical notes,' she said.
As well as dementia-like symptoms, he pointed out other side-effects
which mimic old-age conditions.
As with all medication there are side-effects
. But in my opinion the benefits outweigh any risks."