An exaggerated pronunciation and misspelling of "please," used to express exasperation, disdain, or incredulity. A: "She said that you're the one who's responsible for the error." B: "Oh, puh-leeze! If she hadn't screwed up, none of this would have happened!" Puh-leeze—that's the most ludicrous thing I've ever heard!
exclam. Please!; That is enough! You can’t expect me to accept that! (A long, drawn-out way of saying Please! The tone of voice shows exasperation and disgust. The spelling is highly variable.) I am the one who’s at fault? Puuuleeeze!