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A sentence, phrase, or question used to start a flirtatious conversation with a potential romantic or sexual partner. "Have we met before?" is Ed's favorite pick-up line, even though it has a very low success rate with the ladies. If you hit on girls with that creepy pick-up line, I'm not surprised you keep getting rejected.
See also: line
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.