Also found in: Acronyms.
Very disgruntled, irritated, angry, or outraged. (A euphemistic abbreviation of "pissed off.") John was so PO'd when he found out that someone else had been given the promotion instead of him. There's no point in getting PO'd over a bad grade on your exam. Just study harder next time!
mod. pissed off. The teacher was POed at the whole class.
See also: POe