1. rude slang To greatly anger or irritate someone. "P" is a euphemistic abbreviation of "piss." A noun or pronoun can be used between "P" and "off." I think I might start cycling to work in the morning—this traffic really P's me off! I think I P'd off Janet with my comment earlier.
2. rude slang To depart from somewhere quickly or abruptly. Often used as an imperative. Why don't you just P off if you're not going to help us?
See also: off
Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.