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Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs.
Uptake of oleoyl-chitosan nanoparticles by A549 cells.
Pearson's correlation coefficients (r) between dependent variables Particle size Zeta-potential Cellular uptake Particle size -0.
Average daily chloroform uptake ([micro]g) = {(uptake for chloroform per [micro]g/L chloroform in the water per min spent in activity) x [total time spent in activity (min) over 90 days] x [chloroform concentration in the water ([micro]g/L)} / 90 (days).
Similarly, an individual's average daily uptake of chloroform for ingestion of tap water was calculated as
Average daily chloroform uptake ([micro]g) = (uptake per [micro]g/L chloroform in the water per liter ingested) x [average daily cold tap water (L)] x 0.
Figure 2 shows the uptake via ingestion, showering and bathing, and swimming and the total uptake and total uptake excluding swimming uptake for mothers living in homes supplied with low, medium, and high chloroform concentrations.
s]) between chloroform concentrations in water and total uptake was 0.
The uptake via showering and bathing gave the strongest correlation with the total uptake ([r.
One important purpose of the present study was to establish a no-observed-effect level (NOEL) for perchlorate inhibition of the thyroidal uptake of iodide during 2-week exposure.
The additional studies include investigations of perchlorate pharmacokinetics, inhibition of thyroidal iodide uptake, and effects on serum levels of thyroid hormones and TSH in adult males, pregnant and nursing females, and, to a limited extent, fetuses and pups, at doses in the 0.
An additional and potentially important interspecies difference is evidenced by the rapid up-regulation of thyroidal iodide uptake in rats in response to multiday treatment with perchlorate, a phenomenon not observed in humans.
125]I uptake (presumably measured as the bound fraction) observed on E1 was dose related and much more pronounced at each dose than on E5, when inhibition was observed only in the 3- and 10-mg/kg-day groups.
Following the diet shift, rats exhibited a 50% increase in radioiodine uptake in 1 day (33).
Regression analysis of the E14 uptake relative to baseline for the first 14 subjects predicted that a perchlorate dose of 0.