take someone off
1. Literally, to physically remove something or someone from someone, oneself, or something else. In this usage, a noun or pronoun can be used between "take" and "off." He took his shoes off before entering the house. Someone has taken the picture off the wall. The police began taking passengers off the airplane.
2. To decrease; to remove from an existing amount. In this usage, a noun or pronoun can be used between "take" and "off." They offered to take a further 10% off if we signed up for paper-free billing. I'm trying to take off a few pounds ahead of the wedding so I can fit into my suit.
3. To release something. In this usage, a noun or pronoun can be used between "take" and "off." Please don't take the safety off the gun until you are aiming at the target. He took off the restraining bolt so that the cattle could push their way through the gate.
4. To rise into the air in flight. What time does the plane take off? They've already taken off, so it's too late to say goodbye.
5. To increase in activity very rapidly and to a large degree. Sales really took off after we got that movie star to appear in our advertisements. My career didn't take off until I moved to Los Angeles. The party really took off after 9 PM.
6. To steal or take something without permission. Typically followed by "with (something)" in this usage. The thief took off with my bicycle. I think John took off with the car. He is in so much trouble when he comes back!
7. To leave or move very quickly. The kids took off as soon as they heard the police officers coming toward them. The car took off after the accident before I could get the license plate number.
8. To depart for someplace. In this usage, a form of the pronoun "oneself" can be used between "take" and "off." He took himself off to his grandfather's cabin in the woods to think about all that had happened. Sorry, I need to take off or I'll be late for my meeting.
9. To remove someone from some activity or endeavor. In this usage, a name, noun, or pronoun can be used between "take" and "off." I can't believe they took us off the project after all the work we did for it! She's taking herself off the investigation due to a conflict of interests.
take someone off
tv. to kill someone. (Underworld.) The mob took the witness off a week before the trial.