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1. To depart for or begin traveling to (some place). Make sure you eat a good breakfast before you strike off! I'm striking off for New York tomorrow to attend a business meeting.
2. To cause someone to fall off (of something) by hitting, kicking, pushing, or knocking into them. In this usage, a noun or pronoun is used between "strike" and "off." The jouster struck his opponent off his horse. He struck the lamp off the table with the baseball.
3. To split, sever, or break off something (from something else) with a forceful blow. In this usage, a noun or pronoun is used between "strike" and "off." He struck off a piece of concrete with the swing of his hammer. They spent the day striking chunks of ice off the giant block.
strike something off (of) someone or somethingand strike something off
to knock something off someone or something. (Of is usually retained before pronouns.) She accidentally struck John's hat off of him. She struck off a chunk of ice.
To start a journey or proceed in a new direction: The hikers struck off into the forest.