A rude and angry expression of disgust or dissatisfaction with someone or something, especially indicating that one doesn't want to be associated with the person or do the thing in question. A: "The manager said all staff have to be in tomorrow at 6 AM to help with the stock check." B: "Screw that! There's no way I'm coming in that early!" She treated you like garbage, and now she expects you to help her with the business? Screw her!
rude slang An interjection of angry dismissal or contempt. A: "Wow, you're a lousy mechanic, Ben." B: "Hey, your car's running, isn't it? So screw you!" Screw you! I'll didn't want to eat with you anyway!
Go to hell, as in You won't help after all? Well, screw you! A euphemism for the still ruder fuck you, this slangy term dates from the mid-1900s.