out of (one's) brain(redirected from out of their brains)
out of (one's) brain
Heavily intoxicated by drugs or alcohol, especially to the point of becoming unconscious, nonsensical, or out of control. Primarily heard in UK. I think someone might have spiked Jack's drink with some kind of drug, because he's out of his brain all of a sudden. Jane is a lightweight. Only one or two beers gets totally out of her brain. I had to take my brother away from the party because he was out of his brain on LSD.